Live virus neutralization testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2
نویسندگان
چکیده
SARS-CoV-2 mutations appeared recently and can lead to conformational changes in the spike protein probably induce modifications antigenicity. We assessed neutralizing capacity of antibodies prevent cell infection, using a live virus neutralization test with different strains [19A (initial one), 20B (B.1.1.241 lineage), 20I/501Y.V1 (B.1.1.7 20H/501Y.V2 (B.1.351 lineage)] serum samples collected from populations: two-dose vaccinated COVID-19-naive healthcare workers (HCWs; Pfizer-BioNTech BNT161b2), 6-months post mild COVID-19 HCWs, critical patients. No significant difference was observed between 19A isolates for HCWs However, decrease ability found comparison isolate patients infection. Concerning 20H/501Y.V2, all populations had reduction antibody titers isolate. Interestingly, two variants but not convalescent groups.
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ژورنال
عنوان ژورنال: Emerging microbes & infections
سال: 2021
ISSN: ['2222-1751']
DOI: https://doi.org/10.1080/22221751.2021.1945423